The health benefits of pomegranates have captured the attention of the scientific world and continue to impress as researchers discover new chemical properties that this amazing fruit contains. In a new study out of Switzerland researchers found that a compound known as urolithin A (UA) induces mitophagy both in vitro and in vivo following oral consumption.
Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress…Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. [i]
Data published in the journal Nature UA reported that, UA is derived from, “the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We identified urolithin A (UA) as a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption. In C. elegans, UA prevented the accumulation of dysfunctional mitochondria with age and extended lifespan. Likewise, UA prolonged normal activity during aging in C. elegans, including mobility and pharyngeal pumping, while maintaining mitochondrial respiratory capacity. These effects translated to rodents, where UA improved exercise capacity in two different mouse models of age-related decline of muscle function, as well as in young rats. Our findings highlight the health benefits of urolithin A and its potential application in strategies to improve mitochondrial and muscle function.” [ii]
Scientists have managed to prove pomegranates anti-aging potential: intestinal bacteria transform a molecule contained in the fruit with spectacular results. Although tests in humans are still underway, scientists have already published the initial promising results from animal studies in the journal Nature Medicine.
‘Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents’ published in Nature Medicine, July 2016. If you want to fully grasp the importance of these new findings and understand the connection between ellagitannins and UA then watch the video below.
Author: Gregory Ciola
Gregory Ciola began his publishing career in the year 2000 when he released a ground breaking book on the dangers of genetic engineering. The book’s title was, “GMOs – Beware of the Coming Food Apocalypse!”. Gregory Ciola was one of the first biotech whistle blowers in the natural food industry to alert the public to what was happening to a majority of our foods. Ciola also began publishing a hard-hitting national newsletter in 2001 called “CRUSADOR” that was renamed in 2015 to “The Investigator’s Report”. He is best known for his in-depth interviews with well known book authors and leading health experts.